منابع مشابه
Increased Na+ and K+ currents in small mouse dorsal root ganglion neurons after ganglion compression.
We investigated the effects of chronic compression (CCD) of the L3 and L4 dorsal root ganglion (DRG) on pain behavior in the mouse and on the electrophysiological properties of the small-diameter neuronal cell bodies in the intact ganglion. CCD is a model of human radicular pain produced by intraforaminal stenosis and other disorders affecting the DRG, spinal nerve, or root. On days 1, 3, 5, an...
متن کاملSpinal Solid Cord Compression Malignant Tumors Caused By Children
The medical records of 154 children with solid malignant primary tumors outside the central nervous system were retrospectively reviewed to achieve a better understanding of the incidence, presentation, outcome and treatment options for metastatic spinal cord disease. Of the 154 total, 12 children had symptomatic and 5 had asymptomatic spinal metastases (total 17 cases; 11%). In eight cases, th...
متن کاملDiffering alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury
Voltage-gated sodium channels play important roles in modulating dorsal root ganglion (DRG) neuron hyperexcitability and hyperalgesia after peripheral nerve injury or inflammation. We report that chronic compression of DRG (CCD) produces profound effect on tetrodotoxin-resistant (TTX-R) and tetrodotoxin-sensitive (TTX-S) sodium currents, which are different from that by chronic constriction inj...
متن کاملCB1 receptor localization in rat spinal cord and roots, dorsal root ganglion, and peripheral nerve.
AIM The localization of CB1 receptors in the spinal cord, spinal roots, dorsal root ganglion (DRG), and peripheral nerve of the rat was determined. METHODS We studied the distribution of CB1 cannabinoid receptors by immunohistochemistry using an antibody raised against the N-terminal of the receptor. RESULTS The spinal cord showed numerous transverse fibers labelled for CB1 receptors throug...
متن کاملOpiate Agonists Inhibit Ca2+ Influx in Rat Spinal Cord-Dorsal Root Ganglion Cocultures
The aim of the present study has been to characterize the regulation by opiates of “Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. We have demonstrated that K*-induced depolarization, in the presence of the Ca” channel agonist Bay K8644, stimulated Ca” influx (3-4-fold) via the dihydropyridine class of voltage-dependent Ca” channels. While p and 6 opiates had no effect, K opiat...
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ژورنال
عنوان ژورنال: The Journal of Nervous and Mental Disease
سال: 1909
ISSN: 0022-3018
DOI: 10.1097/00005053-190904000-00022